Brief Report CLINICAL TRIALS AND OBSERVATIONS Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations
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چکیده
Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations Jean-Baptiste Micol, Nicolas Duployez, Nicolas Boissel, Arnaud Petit, Sandrine Geffroy, Olivier Nibourel, Catherine Lacombe, Helene Lapillonne, Pascaline Etancelin, Martin Figeac, Aline Renneville, Sylvie Castaigne, Guy Leverger, Norbert Ifrah, Hervé Dombret, Claude Preudhomme, Omar Abdel-Wahab, and Eric Jourdan
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Distinct forms of tyrosine kinase domain (TKD), juxtamembrane domain, exon 8, and internal tandem duplication (ITD) mutations of c-KIT, were observed in about 46% of core binding factor leukemia (CBFL) patients. To evaluate their prognostic significance, 67 adult patients with CBFL were analyzed to ascertain the cKIT mutation status. In acute myeloid leukemia (AML) with t(8;21), the presence of...
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Mutations in the additional sex comb-like 1 (ASXL1) gene were recently shown in various myeloid malignancies, but they have not been comprehensively investigated in acute myeloid leukemia (AML). In this study, we analyzed ASXL1 mutations in exon 12 in 501 adults with de novo AML. ASXL1 mutations were detected in 54 patients (10.8%), 8.9% among those with normal karyotype and 12.9% among those w...
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